Two richly detailed devotional panels depict Saint Francis and Saint Anthony Abbot as solemn, commanding figures rendered with Signorelli's characteristic sculptural precision and psychological intensity. Saint Francis displays his stigmata and humble Franciscan robes, while Saint Anthony Abbot is distinguished by his traditional iconographic attributes, both saints conveying a sense of austere spiritual authority. The warm, luminous palette and masterful handling of oil on panel reflect the Umbrian and Tuscan influences that defined Signorelli's distinctive late 15th-century style.