A luminous tempera on panel painting with gold ground, this devotional work depicts the Madonna and Child enthroned in regal splendor, flanked by Saint Sebastian and Saint Bernardino of Siena alongside two attending angels. The Master of Staffolo employs the rich, jewel-like qualities of tempera to render intricate details in the figures' drapery and the saints' attributes, while the gilded background radiates a celestial warmth characteristic of the Italian late Gothic tradition. The hierarchical composition and reverent stillness of the figures reflect the devotional intentions of sacred altarpiece painting from the period.