Hunt was a founding member of the Pre Raphaelite Brotherhood alongside Millais and shares the same obsessive botanical precision, jewel toned palette, and morally charged narrative figuration seen in Ophelia. His works like The Lady of Shalott similarly blend literary subjects with hyper detailed natural settings and symbolic floral elements.

Rossetti repeatedly painted Elizabeth Siddal, the same model as Ophelia, and obsessively depicted tragic or dreaming female figures surrounded by dense symbolic vegetation in a richly sensuous Pre Raphaelite oil technique. His literary and Shakespearean subjects, lush natural detail, and haunting feminine mood directly parallel the qualities that define Millais's Ophelia.

Leighton created large scale Victorian oil paintings of serene or melancholic female figures in richly detailed outdoor and water settings drawn from literary and mythological sources, sharing Ophelia's combination of idealized feminine beauty, narrative pathos, lush botanical surroundings, and museum quality 19th century British painting craft.