This tempera on panel painting by Pesellino depicts the Virgin Mary and Christ Child in the intimate, devotional style characteristic of Florentine Renaissance art. The work exemplifies the artist's refined technique and delicate handling of religious subject matter, with careful attention to the tender relationship between mother and child. The verso of the panel features a decorative feigned marbling pattern, a common practice in Italian Renaissance panel painting that added visual interest to the reverse side of portable devotional images.